Gene found as part of a 15.2 kb genetic element in some strains of Staphylococcus aureus ; codes for toxic shock syndrome toxin-1.
(= secretory carrier membrane protein)
Integral membrane proteins of secretory and transport vesicles.
(= signalling lymphocyte-activation molecule; CDw150)
Glycosylated type-I transmembrane protein (70 kD) present on T- and B-cell surfaces that is a high-affinity self-ligand. ...
E. coli phagemid vector, derived from pUC19 and M13MP9.
Cell cycle checkpoint genes found in Schizosaccharomyces pombe. Mutants in wee-1 and wee-2 have normal growth rate but divide earlier so cells are smaller.
(= sodium dodecyl sulphate; sodium lauryl sulphate)
Anionic detergent that at millimolar concentrations will bind to and denature proteins, forming an SDS-protein complex. The ...
(= BRG-1-associated factors)
The SWI/SNF complex-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components ...
(= hCG; human chorionic gonadotrophin)
See chorionic gonadotrophin.
Protein involved in Dpp signalling (Dpp is TGF b -related). MAD ( mothers against dpp S contains a specific DNA-binding activity that activates an enhancer in a Drosophila ...
Two phosphate groups linked by esterification. Released in many of the synthetic steps involving nucleotide triphosphates (eg. protein and nucleic acid elongation). Rapid ...
(= suppressor of cytokine signalling)
Family of proteins (SOCS 1-3 and CIS; 211 amino acids) rapidly induced in response to IL-6 and other cytokines, thought to act as ...
(= mitochondrial outer membrane)
It is used particularly for mitochondrial outer membrane proteins, in conjunction with the molecular mass in kiloDaltons eg. MOM19 and MOM72, ...
(= vascular cell adhesion molecule; CD106)
Cell adhesion molecule (90-110 kD) of the immunoglobulin superfamily expressed on endothelial cells, macrophages, dendritic cells, ...
See voltage-sensitive calcium channel.
(= PTP1D; Shp-2)
An adaptor molecule mediating GRB-2/ras signalling. See Shp.
(= cell-mediated cytotoxicity)
The term is applied to T-lymphocytes that react to antigen by mitogenesis and develop into clones of specific T-effector cells.
Family of adapter proteins able to interact with a range of signalling molecules including c-Raf, Bcr, PI-3-kinase, polyoma middle T-antigen. Bind to phosphorylated serine ...
Monoclonal antibody defining integral membrane protein of chick fibroblasts. Originally thought to recognize a trimeric complex, now thought to recognize two different b1 ...
See diacylglycerol and phosphatidyl inositol.
(= electrocardiograph; electrocardiogram)
A recording of the electrical activity of the heart.
(1) Epithelial membrane antigen; see episialin.
(2) E2F-binding site modulating activity: transcriptional repressor (272 residues, 34 kD) that has some similarity with E2F but ...
See myelin basic protein.
(= white blood cell)
Term includes neutrophils, eosinophils, basophils, monocytes, and lymphocytes.
Human macrophage inflammatory protein 1b (MIP1b).
An avian cytokine produced by chicken cells infected with Rous sarcoma virus.
Entry pre-fix is given as ‘alpha’; alternatively look for main portion of word.
(= a cells)
Cell of the endocrine pancreas (Islets of Langerhans) that form approximately 20% of the population; their opaque spherical granules may contain glucagon. See ...
Better named a-1-antiprotease (a-1-protease inhibitor). A (54 kD) major protein of blood plasma (3mgs/ml in human), part of the a-globulin fraction, and able to inhibit a wide ...
That portion of the sarcomere in which the thick myosin filaments are located. It is anisotropic in polarized light.
Shorter of the two polypeptide chains of insulin (21 residues compared to 30 in the B chain). Many other heterodimeric proteins have their smaller chain designated the A chain, ...
Type of potassium-selective ion channel that is activated by depolarization but only after a preceding hyperpolarization, ie. they are inactivated at rest. Important for ...
Right-handed double-helical DNA with approximately 11 residues per turn. Planes of base-pairs in the helix are tilted 20° away from perpendicular to the axis of the helix. ...
cAMP-regulated protein kinase, sometimes abbreviated PKA to contrast with PKC.
Site on the ribosome to which aminoacyl tRNA attaches during the process of peptide synthesis. See also P-site.
Retrovirus-like particles found in cells. Non-infectious. The mouse genome contains around 1000 copies of homologous sequences.
A monocarboxylic acid extracted from Streptomyces chartreusensis that acts as a mobile-carrier calcium ionophore.
Established line of heteroploid mouse fibroblasts that are deficient in HGPRT.
Common abbreviation for antibody. See immunoglobulins.
Multi-subunit toxin in which there are two major components, an active (A) portion and a portion that is involved in binding (B) to the target cell. The A portion can be ...
Proline-rich basic antibacterial peptides (4 kD) found in the haemolymph of the honeybee. See apidaecins.
(1) Antigen binding cell or antigen binding capacity.
(2) Avidin-biotin peroxidase complex. Used in visualizing antigen. Primary (antigen-specific) antibody is bound first, a ...
Membrane proteins involved in active transport or regulation of ion channel function and having an ATP binding cassette. Most examples are prokaryotic, but important ...
Enzyme complex, product of uvrA, uvrB and uvrC genes from E. coli that mediates incision and excision steps of DNA excision-repair. Enzyme has the ability ...
Abelson leukaemia virus
A replication-defective virus originating from the Moloney murine leukemia virus by acquisition of c-abl. The virus induces B-cell lymphoid leukemias within a few weeks. The ...
Departure from normal; in microscopy two common forms of optical aberration cause problems, spherical aberration in which there is distortion of the image of the magnified ...
Autosomal recessive defect in which there is total absence of apoprotein B (a component of LDL, VLDL and chylomicrons). Characteristic feature is presence of acanthocytes; ...
Spontaneous generation of life from non-living material.
An oncogene, identified in a mouse leukemia, encoding a tyrosine protein kinase. See also ABLV.
The Abelson murine leukaemia virus, a mammalian retrovirus. Its transforming gene, abl, encodes a protein with tyrosine kinase activity closely related to src.
Aminobenzyloxy methylcellulose paper: paper to which single-stranded nucleic acid can be covalently coupled.
ABO blood group system
Probably the best known of the blood group systems, involves a single gene locus that codes for a fucosyl transferase. If the H-gene is expressed then fucose is added to the ...
Viral infection of a cell in which the virus fails to replicate fully, or produces defective progeny. Since part of the viral replicative cycle occurs, its effect on the host can ...
See actin binding proteins.
Actin binding protein (857 amino acids; 92 kD) from Dictyostelium. A small rod-shaped molecule (35-40nm long), dimeric, capable of cross-linking filaments. Has strong sequence ...
Actin binding protein (2647 amino acids; 280 kD) from Dictyostelium, but very similar to filamin from other sources. A long rod-shaped molecule (80nm long), dimeric, with the ...
Actin binding protein (50 kD) from Dictyostelium that crosslinks actin filaments into tight bundles. Identical to elongation factor EF-1a. Calcium insensitive; localized near ...
Homologue of fimbrin. In yeast encoded by SAC6 gene, mutations in which lead to disruption of the actin cytoskeleton.
Toxic lectin from seeds of Abrus precatorius that has a binding site for galactose and related residues in carbohydrate but, because it is monovalent, is not an agglutinin for ...
A cavity within a tissue occupied by pus (chiefly composed of degenerating inflammatory cells), generally caused by bacteria that resist killing by phagocytes.
A growth-inhibiting plant hormone found in vascular plants. Originally believed to be important in abscission (leaf fall), now known to be involved in a number of growth and ...
Any of four different coefficients that indicate the ability of a substance to absorb electromagnetic radiation. Absorbance is defined as the logarithm of the ratio of incident ...
Spectrum of wavelengths of electromagnetic radiation (usually visible and UV light) absorbed by substance. Absorption is determined by existence of atoms that can be excited from ...
Soil amoebae 20-30 mm in diameter that can be grown under axenic conditions and have been extensively used in biochemical studies of cell motility. They have been isolated from ...
Cell with projecting spikes; most commonly applied to erythrocytes where the condition may be caused naturally by abetalipoproteinaemia or experimentally by manipulating the ...
Condition in which red cells of the blood show spiky deformation; symptomatic of abetalipoproteinaemia.
(1) Spinous membranous organelle found in skin fibroblasts from nude mice as a result of chronic ultraviolet irradiation.
(2) Sometimes used as a synonym for coated vesicle ...
Genus of spiny-leaved Mediterranean plants
Medical condition in which there is a low concentration of carbon dioxide in the blood.
(= 1-aminocyclopropane-1-carboxylic acid)
Immediate precursor of the plant hormone ethylene in most vascular plants. Synthesized from S-adenosyl methionine by ACC synthase. ...
(= ACC methylthioadenosine lyase)
Enzyme (65 kD; EC 18.104.22.168) that catalyses conversion of S-adenosylmethionine to ACC, first step in production of the plant hormone ethylene.
Activated Blood Factor V which acts on prothrombin to generate thrombin during blood coagulation.
Cells that interact, usually by physical contact, with T-lymphocytes and that are necessary for induction of an immune response. Include antigen presenting cells, antigen ...
In photosynthesis, pigments that collect light at different wavelengths and transfer the energy to the primary system.
Not made of cells; commonest use is in reference to slime moulds such as Physarum that are multinucleate syncytia.
acellular slime moulds
Protozoa of the Order Eumycetozoida (also termed true slime moulds). Have a multinucleate plasmodial phase in the life cycle.
Descriptive of pieces of chromosome that lack a centromere.
Giant single-celled alga of the Order Dasycycladaceae. The plant is 3-5cm long when mature and consists of rhizoids at the base of a stalk, at the other end of which is a cap ...
Genus of aerobic bacilli that will use ethanol as a substrate to produce acetic acid - thus will convert wine to vinegar.
Acetylated form of coenzyme A that is a carrier for acyl groups, particularly in the tricarboxylic acid cycle.
Addition, either chemically or enzymically, of acetyl groups.
Acetyl ester of choline. Perhaps the best characterized neurotransmitter, particularly at neuromuscular junctions. ACh can be either excitatory or inhibitory, and its ...
An enzyme, found in the synaptic clefts of cholinergic synapses, that cleaves the neurotransmitter acetylcholine into its constituents, acetate and choline, thus limiting the ...
Failure of endochondral ossification responsible for a form of dwarfism; caused by an autosomal dominant mutation. Relatively high incidence (1: 20,000 live births), mostly ...
Genus of aquatic fungi with a branched coenocytic mycelium.
Hydrolytic enzymes that have a low pH optimum. The name usually refers to the phosphatases, glycosidases, nucleases and lipases found in the lysosome. They are secreted during ...
Enzyme (EC 22.214.171.124) with acidic pH optimum, that catalyses cleavage of inorganic phosphate from a variety of substrates. Found particularly in lysosomes and secretory vesicles. ...
Proteolytic enzyme with an acid pH optimum, characteristically found in lysosomes. See proteases.
acid secreting cells
Large specialized cells of the epithelial lining of the stomach (parietal or oxyntic cells) that secrete 0.1N HCl, by means of H+ antiport ATPases on the luminal cell surface.
Citric acid/sodium citrate buffered glucose solution used as an anticoagulant for blood (citrate complexes calcium).
Having an affinity for acidic dyes, particularly eosin; may be applied either to tissues or bacteria.
One class of cells found in the pars distalis of the adenohypophysis.
Non-lysosomal vesicle in which receptor-ligand complexes dissociate because of the acid pH.
Epithelial secretory cells arranged as a ball of cells around the lumen of a gland (as in the pancreas).
Small sac or cavity surrounded by secretory cells.
Animal without a coelom. The Acoelomate Phyla include sponges, coelenterates and lower worms such as nematodes and platyhelminths.
Enzyme of the tricarboxylic acid cycle that catalyses isomerisation of citrate/isocitrate. Isoforms are found both in mitochondrial matrix and cytoplasm.
Classically, the reaction of an organism to a new antigenic challenge and the retention of a memory of this, as opposed to innate immunity. In modern terms, the clonal ...
Order of Protozoa also known as the cellular slime moulds. They normally exist as free-living phagocytic soil amoebae (vegetative cells), but when bacterial prey become scarce, ...
Name originally given to the chemotactic factor produced by cellular slime moulds (Acrasidae) : now known to be cAMP for Dictyostelium discoideum.
A fluorescent vital dye, that intercalates into nucleic acids. The nuclei of stained cells fluoresce green; cytoplasmic RNA fluoresces orange. Acridine orange also stains acid ...
Heterocyclic compounds with a pyridine nucleus. Usually fluorescent and reactive with double stranded DNA as intercalating agents at very low concentrations. Hence dsDNA can be ...
Enlargement of the extremities of the body as a result of the overproduction of growth hormone (somatotropin), eg. by a pituitary tumour.
Serine protease stored in the acrosome of a sperm as an inactive precursor.
A long process actively protruded from the acrosomal region of the spermatozoon following contact with the egg and that assists penetration of the gelatinous capsule.
Vesicle at the extreme anterior end of the spermatozoan, derived from the lysosome.
Human macrophage inflammatory protein 1b.
Actin genes from yeast; ACT1 is the essential (conventional) actin, 89% homologous in sequence with mouse cytoplasmic actin; ACT2 encodes a 44 kD protein 47% identical to ...
Major surface protein (90 kD) of Listeria monocytogenes that acts as the nucleating site for actin polymerization at one pole of the bacterial cell; assembly of the bundle of ...
A protein of 42 kD, very abundant in eukaryotic cells (8-14% total cell protein) and one of the major components of the actomyosin motor and the cortical microfilament ...
actin binding proteins
A diverse group of proteins that bind to actin and that may stabilize F-actin filaments, nucleate filament formation, cross-link filaments, lead to bundle formation etc.
Microfilaments inserted proximally into the plasma membrane and cross-linked by actin binding proteins to form a mechanically resistive network that may support protrusions ...
Vertebrate actin-related protein; 42 kD with 54% sequence homology with muscle actin and 69% similarity with cytoplasmic actin - more similar to conventional actin than to ...
Common beadlet anemone; a coelenterate. See equinatoxins.
Thickened area of skin as a result of excessive exposure to sunlight - particularly common in those with very fair skin.
Protein (115 kD) from Erlich ascites cells that gelates and bundles microfilaments.
Order of Gram positive bacteria, widespread in soil, compost, and aquatic habitats. Most are saprophytic, but there are a few pathogens; some produce important antibiotics. ...
A mixture of antibiotics, actinomycins C1, C2 and actinomycin D elaborated by a species of Streptomyces.
Antibiotic from Streptomyces spp. that by binding to DNA blocks the movement of RNA polymerase and prevents RNA synthesis in both pro- and eukaryotes.
Species of Heliozoa often used in studies on microtubule stability: the axopodia are supported by a bundle of cross-linked microtubules arranged in a complex double-spiral ...
Species of Heliozoathat is multinucleate. Remarkable for its long radial protruding axopodia that contain complex double spiral arrangements of many microtubules. It catches prey ...
An electrical pulse that passes along the membranes of excitable cells, such as neurons, muscle cells, fertilized eggs and certain plant cells. The precise shape of action ...
The relationship between the frequency (wavelength) of a form of radiation, and its effectiveness in inducing a specific chemical or biological effect.
A macrophage (mononuclear phagocyte) that has been stimulated by lymphokines and that has greatly enhanced cytotoxic and bactericidal potential
(of egg) Normally brought about by contact between spermatozoon and egg membrane. Activation is the first stage in development and occurs independently of nuclear fusion. The ...
The energy required to bring a system from the ground state to the level at which a reaction will proceed.
Immunity resulting from the normal response to antigen. Only really used to contrast with passive immunity in which antibodies or sensitised lymphocytes are transferred from ...
The region of a protein that binds to substrate molecule(s) and facilitates a specific chemical conversion. Produced by juxtaposition of amino acid residues as a consequence of ...
Often defined as transport up an electrochemical gradient. More precisely defined as unidirectional or vectorial transport produced within a membrane-bound protein complex by ...
Site of transmitter release on presynaptic terminal at chemical synapses. At the neuromuscular junction active zones are located directly across the synaptic cleft from ...
b subunits of inhibin (which is an ab heterodimer) ; since there are two isoforms, A and B, there are three forms of activin, AA, BB and AB. Receptor has serine/threonine ...
Induced in early Xenopus blastomeres by activin, Vg-1 and TGF b, binds to activin-response element in the mix-2 homeobox gene. The ARF complex contains XMAD2, a Xenopus ...
Protein, 9.7 kD from Acanthamoeba castellani. Potent inhibitor of actin polymerization under certain conditions, possibly by binding to actin oligomers rendering them ...
Monomeric protein (20 kD) from echinoderm eggs. Seems to link actin filaments to inner surface of plasma membrane by their barbed ends.
Site of actin filament nucleation in sperm of some echinoderms in which the acrosomal process is protruded by rapid assembly of a parallel microfilament bundle.
Generally: a motor system that is thought to be based on actin and myosin. The essence of the motor system is that myosin makes transient contact with the actin filaments ...
An actin depolymerizing factor (ADF) (13-15 kD) from protozoa ( Toxoplasma gondii, Acanthamoeba castellanii ) that will sever actin filaments and sequester G actin. Binds ...
Protein (65 kD) originally thought to cap pointed end of microfilaments, isolated from vertebrate macrophages.
(1) Sharp or pointed.
(2) Of diseases; coming rapidly to a crisis - not persistent (chronic).
Response of vertebrate body to insult or infection; characterized by redness (rubor), heat (calor), swelling (tumor), pain (dolor), and sometimes loss of function. Changes occur ...
acute phase protein
Proteins found in the serum of organisms showing acute inflammation. In particular C-reactive protein and serum amyloid A protein.
acute phase reaction
Response to acute inflammation involving the increased synthesis of various plasma proteins (acute phase proteins).
acutely transforming virus
Retrovirus that rapidly transforms cells, by virtue of possessing one or more oncogenes. Archetype: Rous sarcoma virus.
(2) alpha-aminoadipylcysteinyl-valine, precursor for isopenicillin synthesis.
(= alpha-aminoadipylcysteinyl-valine synthase)
Enzyme responsible for an early step in cephalosporin synthesis. ACV is acted upon by isopenicillin N synthase to produce ...
(= ACV; 2-(hydroxyethoxy) methyl guanine)
Antiviral agent that is an analogue of guanosine and inhibits DNA replication of viruses. Particularly successful against herpes ...
Introduction of an acyl (RCO-) group into a molecule: for example the formation of an ester between glycerol and fatty acid to form mono-, di-, or tri-acylglycerol, or the ...
A change in sensory or excitable cells upon repeated stimulation, that reduces their sensitivity to continued stimulation. Those cells that show rapid adaptation are known as ...
Proteins of 100-110 kD found as part of the adaptorcomplex.
A protein complex associated with coated vesicles. Adaptors have been shown to promote the in vitro assembly of clathrin cages and to bind to the cytoplasmic domains of ...
Chronic insufficiency of the adrenal cortex as a result of tuberculosis or, specific autoimmune destruction of the ACTH-secreting cells.
Cell surface molecules, particularly on endothelial cells believed to be involved in controlling the location of migrating cells, especially in lymphocyte homing. Probably act ...
Calmodulin-binding protein associated with the membrane skeleton of erythrocytes. A substrate for protein kinase C, it binds to spectrin-actin complexes (but only weakly to ...
Large muscle of bivalve molluscs that is responsible for holding the two halves of the shell closed. Its unusual feature is its ability to maintain high tension with low energy ...
One of the bases found in nucleic acids and nucleotides. In DNA, it pairs with thymine.
Prefix indicating association with, or similarity to, glandular tissue.
Malignant neoplasia of a glandular epithelium, or carcinoma showing gland-like organization of cells.
Anterior lobe of the pituitary gland; responsible for secreting a number of hormones and containing a comparable number of cell types.
Benign tumour of glandular epithelium.
The nucleoside formed by linking adenine to ribose.
Four adenosine receptors have been identified, A1, A2A, A2B, and A3. All are seven membrane-spanning G-protein coupled. There is considerable difference in properties of ...
Benign tumour of epithelial origin (adenoma) in which cells have flattened morphology as opposed to cuboidal or columnar.
Large group of viruses first isolated from cultures of adenoids. The capsid is an icosahedron of 240 hexons and 12 pentons and is in the form of a base and a fibre with a ...
Enzyme that produces cAMP (cyclic AMP) from ATP and acts as a signal-transducer coupling hormone binding to change of cytoplasmic cAMP levels. The name strictly refers to ...
(1) Actin Depolymerizing Factor (19 kD) ; regulates actin polymerization in developing chick skeletal muscle. Has the ability to depolymerize microfilaments and bind ...
(= ADF-homology domain)
An actin-binding module found in an extensive family of proteins with three phylogenetically distinct classes, ADF/cofilins, twinfilins and drebin/ABP-1s.
Specialized cell-cell junction into which are inserted microfilaments (in which case also known as zonula adherens), or intermediate filaments (macula adherens or spot ...
General term for molecules involved in adhesion, but its use is restricted in Microbiology where it refers to bacterial surface components.
Another term for a focal adhesion, a discrete area of close contact between a cell and a non-cellular substratum, with cytoplasmic insertion of microfilaments and considerable ...
(1) In Gram negative bacteria, a region where the outer membrane and the plasmalemma appear to fuse. May be important in export of proteins or viral entry.
(2) Used rather ...
Mesenchymal cell in fat tissue that has large lipid-filled vesicles. There may be distinct types in white and brown fat. 3T3-L1 cells are often used as a model system; they can ...
Adipocytes from subcutaneous fat lose fat globules and develop a fibroblastic appearance when grown in culture. Unlike skin fibroblasts they will take up fat from serum taken ...
Fibrous connective tissue with large numbers of fat-storing cells, adipocytes.
A serine protease with complement factor D activity. Synthesized by adipocytes. Altered levels are characteristic of some genetic and acquired obesity syndromes.
Additional components added to a system to affect action of its main component, typically to increase immune response to an antigen. See Freund\'s adjuvant.
Inhibitor of kinesin, isolated from sponge ( Haliclona spp.). Binds to motor domain of kinesin, mimicking tubulin.
Immunity acquired as a result of the transfer of lymphocytes from another animal.
Adenosine diphosphate. Unless otherwise specified is the nucleotide 5\'ADP, adenosine bearing a diphosphate (pyrophosphate) group in ribose-O-phosphate ester linkage at ...
A form of post-translational modification of protein structure involving the transfer to protein of the ADP-ribosyl moiety of NAD. Believed to play a part in normal cellular ...
Ubiquitous GTP-binding protein, approximately 20 kD, N-myristoylated, stimulates cholera toxin ADP-ribosylation. Mediates binding of non-clathrin coated vesicles and AP1 ...
Endocrine gland adjacent to the kidney. Distinct regions (cortex and medulla) produce different ranges of hormones.
A hormone secreted (with noradrenaline) by the medulla of the adrenal gland, and by neurons of the sympathetic nervous system, in response to stress. The ...
A neuron is adrenergic if it secretes adrenaline at its terminals. Many neurons of the sympathetic nervous systemare adrenergic.
Receptors for noradrenaline and adrenaline. All are seven membrane spanning G-protein coupled receptors linked variously either to adenylate cyclase or phosphoinositide ...
A peptide hormone produced by the pituitary gland in response to stress (mediated by corticotrophin releasing factor, a 41 residue peptide, from the hypothalamus). ...
An antibiotic that intercalates into RNA and DNA. Related to daunomycin.
Actin regulating protein (74 kD) isolated from adrenal medulla. Has severing, nucleating and capping activities similar to those of gelsolin, but does not crossreact ...
A constant, under defined conditions, that relates the binding of a molecule to a matrix as a function of the weight of matrix, for example in a column.
Outer coat of the wall of vein or artery, composed of loose connective tissue that is vascularized. Generally used to mean outer covering of an organ.
Genus of mosquitos, several of which transmit diseases of man. A. aegypti is the vector of Yellow Fever.
Hydrozoan jellyfish (a coelenterate) from which green fluorescent protein (GFP) was isolated. Aequorin can be isolated from A. victoria and A. forskaolea.
Protein (30 kD) extracted from jellyfish ( Aequorea aequorea ) that emits light in proportion to the concentration of calcium ions. Used to measure calcium concentrations, but ...
Form of parenchyma with large air spaces that gives buoyancy to aquatic plants.
Organisms that rely on oxygen.
Controlled process by which carbohydrate is oxidized to carbon dioxide and water, using atmospheric oxygen, to yield energy.
Channel-forming bacterial exotoxin produced by Aeromonas hydrophila as a 50 kD protoxin that later has a 43 residue C-terminal peptide cleaved off to generate the active toxin. ...
Genus of Gram negative bacteria some species of which are pathogenic. A. salmonicida causes furunculosis in fish.
A taxis in response to oxygen (air).
(1) Activation function domain 2 of steroid receptors.
(2) Antiflammin-2, a synthetic peptide inhibitor of PLA2.
Leading towards; afferent nerves lead towards the central nervous system, afferent lymphatics towards the lymph node. The opposite of efferent.
An expression of the strength of interaction between two entities, eg. between receptor and ligand or between enzyme and substrate. The affinity is usually characterized by the ...
Chromatography in which the immobile phase (bed material) has a specific biological affinity for the substance to be separated or isolated, such as the affinity of an antibody ...
Labelling of the active site of an enzyme or the binding site of a receptor by means of a reactive substance that forms a covalent linkage once having bound. Linkage is often ...
A group of highly toxic substances produced by the fungus Aspergillus flavus, and other species of Aspergillus, in stored grain or mouldy peanuts. They cause enlargement and ...
Sex-linked genetic defect that leads to the complete absence of immunoglobulins (IgG, IgM, and IgA) in the plasma as a result of the failure of pre-B cells to differentiate. ...
A polysaccharide complex extracted from seaweed (Rhodophyceae) and used as an inert support for the growth of cells, particularly bacteria and some cancer cell lines (eg. ...
A galactan polymer purified from agar that forms a rigid gel with high free water content. Primarily used as an electrophoretic support for separation of macromolecules. ...
Toxins from the American funnel web spider, Agalenopsis aperta. The m -toxins are 36-38 residue peptides that act on insect but not vertebrate voltage-sensitive sodium channels. ...
The formation of adhesions by particles or cells to build up multicomponent aggregates, otherwise termed agglutinates or flocs. Distinguished from aggregation by the fact that ...
Agents causing agglutination, eg. antibodies, lectins, polylysine.
The antigen (in the case of antibody) or ligand (in the case of lectin) with which an agglutinin reacts.
The major structural proteoglycan of cartilage. It is a very large and complex macromolecule, comprising a core protein of 210 kD to which are linked around 100 chondroitin ...
The process of forming adhesions between particles such as cells. Aggregation is usually distinguished from agglutination by the slow nature of the process in that not every ...
Agonist-regulated actin-filament barbed-end capping protein (70 kD) that inhibits microfilament polymerization, isolated from Dictyostelium. Interestingly it is regulated by ...
Scorpion toxins (peptides) that inhibit potassium channels. Closely related to kaliotoxin.
Enzyme that degrades agmatine to putrescine.
A metabolite of arginine via arginine decarboxylase, is metabolized to putrescine by agmatinase. Suppresses polyamine biosynthesis and ...
(1) In neurobiology, of a neuron or muscle; one that aids the action of another. If the two effects oppose each other, then they are known as antagonistic.
(2) In ...
Major structural proteins of the membrane matrix, constituting approximately 15% of total plasma membrane proteins of P815 mastocytoma cells. They form large ...
Central American rodent that has given its name to a grey flecked coat coloration in mice caused by alternate light and dark bands on individual hairs. The gene codes for a 131 ...
A class of extracellular proteoglycan, found in many higher-plant tissues, and secreted by many suspension-cultured plant cells. Contains 90-98% ...
Synaptic vesicles that do not have a granular appearance in EM; 40-50nm in diameter, with membrane only 4-5nm thick. Characteristic of peripheral cholinergic synapses; (see also ...
Portion of antigen that interacts with an MHC molecule.
Secreted protein (200 kD) isolated from the synapse-rich electric organ of Torpedo californica that induces the formation of synaptic specializations on myotubes in culture. ...
A Gram negative, rod-shaped flagellated bacterium responsible for crown gall tumour in plants. Following infection the T1 plasmid from the bacterium becomes integrated into the ...
Cytoplasmic receptor for aryl hydrocarbons: once ligand is bound it translocates to the nucleus and binds to xenobiotic response element. Contains basic helix-turn-helix ...
(= Acquired Immune Deficiency Syndrome)
Disease caused by infection with HIV (also called LAV or HTLV-3 in the early literature) virus, resulting in a deficiency of T-helper ...
A fermenter in which circulation of the culture medium and aeration is achieved by injection of air into some lower part of the fermenter. Usually not suitable for animal cell ...
(= A kinase anchoring protein)
Scaffold protein from mammalian cells to which Protein Kinase A (PKA), calcineurin and Protein Kinase C(PKC) all bind. PKC apparently binds at ...
Product of the normal gene homologue of v- akt, the transforming oncogene of AKT8 virus. A serine/threonine kinase (58 kD) with SH2 and PH domains, activated by PI3kinase ...
A replication competent murine leukemia virus occurring endogenously in some mouse strains.
Enzyme responsible for the synthesis of 5-aminolevulinic acid. Defects in the enzyme cause microcytic anaemia because activity is essential for haem formation.
A polyene pore-forming ionophore that forms relatively nonspecific anion or cation transporting pores in plasma membranes or artificial lipid membranes. These pores may be ...
Normally refers to L-a-alanine, the aliphatic amino acid found in proteins. The isomer b-alanine is a component of the vitamin pantothenic acid and thus also of coenzyme A.
A small signal molecule in bacteria that induces an alteration of metabolism as a response to stress. Many metabolic responses may be altered by a single alarmone.
Condition in which no melanin (or other pigment) is present.
Organism deficient in melanin biosynthesis. Hair and skin are unpigmented and the retinal pigmented epithelium is transparent, making the eyes appear red.